(Ph.D.) Pohang University of Science and Technology, Korea (1996)
(M.S.) Pohang University of Science and Technology, Korea (1992)
(B.S.) SungKyunKwan University, Korea (1990)
약력/경력
2020-Current: Director, BK21 FOUR Project
2017- Current: Professor, Sungkyunkwan University
2013-2017: Professor, Dongguk University
2003-2013: Senior Researcher, Korea Research Institute of Bioscience & Biotechnology(KRIBB)
2000. 09-2003.08: Postdoctoral Fellow, Harvard University
학술지 논문
(2024)
Prodigious catalytic activity towards reduction of 4-hydroxynitrobenzene sodium salt using one-pot synthesized ZnO-Pd nanobolts.
SURFACES AND INTERFACES.
44,
1
(2023)
Methyl Syringate Stimulates Glucose Uptake by Inhibiting Protein Tyrosine Phosphatases Relevant to Insulin Resistance.
LIFE-BASEL.
13,
6
(2022)
Network pharmacology and molecular docking approaches to elucidate the potential compounds and targets of Saeng-Ji-Hwang-Ko for treatment of type 2 diabetes mellitus.
COMPUTERS IN BIOLOGY AND MEDICINE.
149,
(2022)
Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death.
PLOS ONE.
17,
6
(2022)
Ethyl Gallate Dual-Targeting PTPN6 and PPAR gamma Shows Anti-Diabetic and Anti-Obese Effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
23,
9
(2022)
Site-Selective Antibody-Drug Conjugation by a Proximity-Driven S to N Acyl Transfer Reaction on a Therapeutic Antibody.
JOURNAL OF MEDICINAL CHEMISTRY.
65,
7
(2022)
Chebulinic Acid Suppresses Adipogenesis in 3T3-L1 Preadipocytes by Inhibiting PPP1CB Activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
23,
2
(2021)
Nepetin Acts as a Multi-Targeting Inhibitor of Protein Tyrosine Phosphatases Relevant to Insulin Resistance.
CHEMISTRY & BIODIVERSITY.
19,
1
(2021)
Water-soluble coenzyme Q(10) provides better protection than lipid-soluble coenzyme Q(10) in a rat model of chronic tacrolimus nephropathy.
KOREAN JOURNAL OF INTERNAL MEDICINE.
36,
4
(2021)
Linoleic acid exerts antidiabetic effects by inhibiting protein tyrosine phosphatases associated with insulin resistance.
JOURNAL OF FUNCTIONAL FOODS.
83,
104532
(2021)
Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
MOLECULES.
26,
6
(2021)
A FRET-Based Fluorescent Probe to Screen Anticancer Drugs, Inhibiting p73 Binding to MDM2.
CHEMBIOCHEM.
22,
5
(2021)
A FRET-Based Fluorescent Probe to Screen Anticancer Drugs, Inhibiting p73 Binding to MDM2.
CHEMBIOCHEM.
22,
5
(2021)
Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities.
ARCHIVES OF PHARMACAL RESEARCH.
44,
3
(2021)
Sulfamoylbenzamide-based Capsid Assembly Modulators for Selective Inhibition of Hepatitis B Viral Replication.
ACS MEDICINAL CHEMISTRY LETTERS.
12,
2
(2021)
Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2).
MOLECULES.
26,
4
(2021)
Metabolite Profile of Cucurbitane-Type Triterpenoids of Bitter Melon (Fruit of Momordica charantia) and Their Inhibitory Activity against Protein Tyrosine Phosphatases Relevant to Insulin Resistance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
69,
6
(2020)
Photoconjugation of an Fc-Specific Peptide Enables Efficient DAR 2 Antibody-Drug Conjugate Formation.
ORGANIC LETTERS.
22,
21
(2020)
The therapeutic efficacy of water-soluble coenzyme Q(10) in an experimental model of tacrolimus-induced diabetes mellitus.
KOREAN JOURNAL OF INTERNAL MEDICINE.
35,
6
(2020)
Identification of Vaccinia-H1 Related Phosphatase as an Anticancer Target for 1,2,3,4,6-O-Pentagalloylglucose.
CHEMISTRY & BIODIVERSITY.
17,
2
특허/프로그램
코엔자임 Q10 가용화 조성물 및 이의 제조방법(A composition for solubilizing coenzyme Q10 and method for preparing the same).
16/094,042.
20200303.
미국
코엔자임 Q10 가용화 조성물 및 이의 제조방법(A composition for solubilizing coenzyme Q10 and method for preparing the same).
2017254294.
20190730.
오스트레일리아
ＩｇＧ Ｆｃ 위치선택적 결합 펩티드 및 이를 포함하는 하이브리드 분자(A site-selective binding peptide for IgG Fc and a hybrid molecule comprising the same).
10-2012-0072531.
20190729.
대한민국
코엔자임 Q10 가용화 조성물 및 이의 제조방법(A composition for solubilizing coenzyme Q10 and method for preparing the same).
10-1905-0100000.
20180928.
대한민국
미셀 형성용 전구체(Precursor for preparing micelle).
10-1768-7600000.
20170809.
대한민국
면역글로불린 Ｇ의 Ｆｃ 부위에 선택적으로 결합하는 신규펩타이드 및 그의 제조방법(Novel peptides with specific binding to Fc domain of IgG and their preparation methods).
10-2014-0066395.
20161004.
대한민국
항체의 Ｆｃ 부위 결합 펩타이드를 이용한 항체 정제용 흡착 칼럼(Adsorbent columns using antibody Fc―binding peptide).
10-2012-0075883.
20160331.
대한민국
펩타이드 혼성체를 사용한 배향성이 조절된 항체단분자막의 제조방법(Method for preparing antibody monolayers which have controlled orientation using peptide hybrid).
10-2007-0098852.
20090930.
대한민국
수상/공훈
2021 과학기술유공 국무총리 표창
항체 FC-부위 선택적 결합 펩타이드를 활용한 항체-약물 복합체의 개발 (한국연구재단)
영장류 유래 세포를 이용한 아밀로이드 베타타 펩타이드 플라크 형성 기전 연구 및 억제제 검색시스템 개발 (한국생명공학연구원)
FcRn 기반 개인 맞춤형 차세대 ADC 항암파이프라인 개발 (한국연구재단)
무표지 검출시스템 개발을 통한 단백질 인산화 조절 전통천연물의 표적 검증 (한국연구재단)
혈관투과성 측정 및 제어를 위한 기능성 바이오나노컴포지트 개발 (한국연구재단)
항체 약물 접합 조절이 가능한 펩타이드 링커 기술을 이용한 신규 항체 약물 접합체 개발 (연구성과실용화진흥원)
학술회의논문
(2019)
Site-selective conjugation of antibodies without mutation.
The Fourth A3 Roundtable Meeting on Chemical Probe Research Hub.
일본
(2019)
화학반응에 의한 위치-선택적 항체 구조변형.
Big C 바이오인천 글로벌 컨퍼런스.
대한민국
(2017)
Clustering Effect of Interleukin-1 Receptor Antagonist on the Ferritin Nanocage.
대한 나노 의학회 정기 학술대회.
대한민국
(2017)
ScFv-Ferritin as an Advanced Drug Delivery Platform.
대한 나노 의학회 정기 학술대회.
대한민국
